Hereditary cancer complete genetic testing menu

This overview offers a quick glance at the broad offerings available to you and your patients.

Comprehensive and guideline-based hereditary cancer panels

Test code Test name Description
38600 Comprehensive Hereditary Cancer Panel
(66 genes)
Multi-cancer 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2
38611 Guideline-Based Hereditary Cancer Panel
(32 genes)
Multi-cancer 32-gene panel tests for variants in these genes: APC, ATM, AXIN2, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p16,p14), CHEK2, EPCAM, GREM1, HOXB13, MLH1, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, POLD1, POLE, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53

Cancer-specific panels

Test code Test name Description
38621 Hereditary Breast Cancer Panel (16 genes) Tests for variants in 16 genes predominantly associated with breast, prostate cancer, and other tissues including these genes: ATM, BRCA1, BRCA2, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, STK11, TP53
38631 Hereditary Colorectal Cancer Panel (19 genes) Tests for variants in 19 genes associated with increased risk for colorectal cancer including: APC, AXIN2, BMPR1A, CDH1, EPCAM, GREM1, MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53
38641 Hereditary Endocrine Cancer Panel (12 genes) Tests for variants in 12 genes associated with increased risk for paragangliomas, pheochromocytomas, and endocrine cancer: FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL
92587 BRCA Panel Plus (7 genes) Detects variants in BRCA1, BRCA2, CDH1, PALB2, PTEN, STK11, TP53

Hereditary cancer syndrome panels

Test code Test name Description
Breast cancer syndrome
91863 BRCA Panel (BRCA1, BRCA2) Detects variants in the BRCA1 and BRCA2 genes which are the most common causes of hereditary breast and ovarian cancers
91864 BRCA Ashkenazi Jewish Screen Detects 3 variants within BRCA1 and BRCA2 that are commonly found in the Ashkenazi Jewish population
92140 BRCA Ashkenazi Jewish Screen w/Reflex to BRCA Panel (BRCA1, BRCA2) Ashkenazi Jewish screen; if negative reflex to BRCA Panel-BRCA1 and BRCA2
91866 BRCA1 and BRCA2 Deletion and Duplication Detects large deletion/duplication variants in the BRCA1 and BRCA2 genes which are not detectable by DNA sequencing
Lynch syndrome
91461 Lynch Syndrome Panel (5 genes) Detects pathogenic variants in the MLH1, MSH2, MSH6, PMS2, and EPCAM (del/dup only) genes
Other cancer risks
38651 Nevoid Basal Cell Carcinoma (NBCCS) (Gorlin) Syndrome Panel (PTCH1, SUFU) Detects variants in PTCH1 and SUFU
38661 Tuberous Sclerosis Complex Panel (TSC1, TSC2) Detects variants in TSC1 and TSC2
94053 Juvenile Polyposis Panel (BMPR1A, SMAD4) Detects pathogenic and VUS variants in the BMPR1A and SMAD4 genes

Single-gene and single-site tests

Test code Test name Description
93945 Hereditary Cancer Single Site(s) APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A (p16, p14), CHEK2, DICER1, EGFR, EPCAM, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, GREM1, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2
See description column Single-gene tests* APC – 93797, ATM – 38802, BAP1 – 38803, BLM – 38804, CDH1 – 92568, CDKN2A – 93939, CHEK2 – 93940, EPCAM/MSH2 – 91471, FH – 38805, FLCN – 38806, HOXB13 – 38807, MEN1 – 93942, MITF – 38808, MLH1 – 91460, MSH6 – 91458, MUTYH – 93944, NF1 – 93941, PALB2 – 92571, PMS2 – 91457, PTEN – 92566, RET – 93796, SMARCA4 – 38809, STK11 – 92565, TP53 – 92560, VHL – 93943

* All panel components are available individually

Comprehensive and guideline-based hereditary cancer panels

Comprehensive Hereditary Cancer Panel (66 genes)

Test code: 38600

Multi-cancer, 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2

Guideline-Based Hereditary Cancer Panel (32 genes)

Test code: 38611

Multi-cancer, 32-gene panel tests for variants in these genes: APC, ATM, AXIN2, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p16,p14), CHEK2, EPCAM, GREM1, HOXB13, MLH1, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, POLD1, POLE, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53

Cancer-specific panels

Hereditary Breast Cancer Panel (16 genes)

Test code: 38621

Tests for variants in 16 genes predominantly associated with breast, prostate cancer, and other tissues including these genes: ATM, BRCA1, BRCA2, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, STK11, TP53

Hereditary Colorectal Cancer Panel (19 genes)

Test code: 38631

Tests for variants in 19 genes associated with increased risk for colorectal cancer including: APC, AXIN2, BMPR1A, CDH1, EPCAM, GREM1, MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53

Hereditary Endocrine Cancer Panel (12 genes)

Test code: 38641

Tests for variants in 12 genes associated with increased risk for paragangliomas, pheochromocytomas, and endocrine cancer: FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

BRCA Panel Plus (7 genes)

Test code: 92587

Detects variants in BRCA1, BRCA2, CDH1, PALB2, PTEN, STK11, TP53

Hereditary cancer syndrome panels
Breast cancer syndrome
BRCA Panel (BRCA1, BRCA2)
Test code: 91863

Detects variants in the BRCA1 and BRCA2 genes which are the most common causes of hereditary breast and ovarian cancers

BRCA Ashkenazi Jewish Screen
Test code: 91864

Detects 3 variants within BRCA1 and BRCA2 that are commonly found in the Ashkenazi Jewish population

BRCA Ashkenazi Jewish Screen w/Reflex to BRCA Panel (BRCA1, BRCA2)
Test code: 92140

Ashkenazi Jewish screen; if negative reflex to BRCA Panel-BRCA1 and BRCA2

BRCA1 and BRCA2 Deletion and Duplication
Test code: 91866

Detects large deletion/duplication variants in the BRCA1 and BRCA2 genes which are not detectable by DNA sequencing

Lynch syndrome
Lynch Syndrome Panel (5 genes)
Test code: 91461

Detects pathogenic variants in the MLH1, MSH2, MSH6, PMS2, and EPCAM (del/dup only) genes

Other cancer risks
Nevoid Basal Cell Carcinoma (NBCCS) (Gorlin) Syndrome Panel (PTCH1, SUFU)
Test code: 38651

Detects variants in PTCH1 and SUFU

Tuberous Sclerosis Complex Panel (TSC1, TSC2)
Test code: 38661

Detects variants in TSC1 and TSC2

Juvenile Polyposis Panel (BMPR1A, SMAD4)
Test code: 94053

Detects pathogenic and VUS variants in the BMPR1A and SMAD4 genes

Single-gene and single-site tests
Hereditary Cancer Single Site(s)
Test code: 93945

APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A (p16, p14), CHEK2, DICER1, EGFR, EPCAM, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, GREM1, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2

Single-gene tests*

APC – 93797, ATM – 38802, BAP1 – 38803, BLM – 38804, CDH1 – 92568, CDKN2A – 93939, CHEK2 – 93940, EPCAM/MSH2 – 91471, FH – 38805, FLCN – 38806, HOXB13 – 38807, MEN1 – 93942, MITF – 38808, MLH1 – 91460, MSH6 – 91458, MUTYH – 93944, NF1 – 93941, PALB2 – 92571, PMS2 – 91457, PTEN – 92566, RET – 93796, SMARCA4 – 38809, STK11 – 92565, TP53 – 92560, VHL – 93943

* All panel components are available individually

Simplified ordering process

Easily find detailed information for each test in the Quest Diagnostics test directory and order your Hereditary Cancer test collection kits by completing this online form. To complete the online order form, you’ll need your Quest Diagnostics Account Number.

If you aren’t sure if you have an account, call us at 1.866.MY.QUEST (1.866.697.8378) and we’ll be happy to look it up. We can quickly create an account for you today, so you’ll have everything you need to ensure seamless service—from kit delivery, to speedy order processing, to result delivery—including requisition forms, customer service contact information, and scheduled pick-up service when you need it.

Once your account is set up, ask the Client Services Representative to send your Quest Advanced Hereditary Cancer starter kits to you or complete the online form.

As always, for clinical consultation on test selection and results interpretation, you can call 1.866.GENE.INFO (1.866.436.3463).

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