Hereditary cancer complete genetic testing menu
This overview offers a quick glance at the broad offerings available to you and your patients.
Comprehensive and guideline-based hereditary cancer panels
| Test code | Test name | Description |
|---|---|---|
| 38600 | Comprehensive Hereditary Cancer Panel
(66 genes) |
Multi-cancer 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2 |
| 38611 | Guideline-Based Hereditary Cancer Panel
(32 genes) |
Multi-cancer 32-gene panel tests for variants in these genes: APC, ATM, AXIN2, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p16,p14), CHEK2, EPCAM, GREM1, HOXB13, MLH1, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, POLD1, POLE, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53 |
Cancer-specific panels
| Test code | Test name | Description |
|---|---|---|
| 38621 | Hereditary Breast Cancer Panel (16 genes) | Tests for variants in 16 genes predominantly associated with breast, prostate cancer, and other tissues including these genes: ATM, BRCA1, BRCA2, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, STK11, TP53 |
| 38631 | Hereditary Colorectal Cancer Panel (19 genes) | Tests for variants in 19 genes associated with increased risk for colorectal cancer including: APC, AXIN2, BMPR1A, CDH1, EPCAM, GREM1, MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53 |
| 38641 | Hereditary Endocrine Cancer Panel (12 genes) | Tests for variants in 12 genes associated with increased risk for paragangliomas, pheochromocytomas, and endocrine cancer: FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL |
| 92587 | BRCA Panel Plus (7 genes) | Detects variants in BRCA1, BRCA2, CDH1, PALB2, PTEN, STK11, TP53 |
Hereditary cancer syndrome panels
| Test code | Test name | Description |
|---|---|---|
| Breast cancer syndrome | ||
| 91863 | BRCA Panel (BRCA1, BRCA2) | Detects variants in the BRCA1 and BRCA2 genes which are the most common causes of hereditary breast and ovarian cancers |
| 91864 | BRCA Ashkenazi Jewish Screen | Detects 3 variants within BRCA1 and BRCA2 that are commonly found in the Ashkenazi Jewish population |
| 92140 | BRCA Ashkenazi Jewish Screen w/Reflex to BRCA Panel (BRCA1, BRCA2) | Ashkenazi Jewish screen; if negative reflex to BRCA Panel-BRCA1 and BRCA2 |
| 91866 | BRCA1 and BRCA2 Deletion and Duplication | Detects large deletion/duplication variants in the BRCA1 and BRCA2 genes which are not detectable by DNA sequencing |
| Lynch syndrome | ||
| 91461 | Lynch Syndrome Panel (5 genes) | Detects pathogenic variants in the MLH1, MSH2, MSH6, PMS2, and EPCAM (del/dup only) genes |
| Other cancer risks | ||
| 38651 | Nevoid Basal Cell Carcinoma (NBCCS) (Gorlin) Syndrome Panel (PTCH1, SUFU) | Detects variants in PTCH1 and SUFU |
| 38661 | Tuberous Sclerosis Complex Panel (TSC1, TSC2) | Detects variants in TSC1 and TSC2 |
| 94053 | Juvenile Polyposis Panel (BMPR1A, SMAD4) | Detects pathogenic and VUS variants in the BMPR1A and SMAD4 genes |
Single-gene and single-site tests
| Test code | Test name | Description |
|---|---|---|
| 93945 | Hereditary Cancer Single Site(s) | APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A (p16, p14), CHEK2, DICER1, EGFR, EPCAM, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, GREM1, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2 |
| See description column | Single-gene tests* | APC – 93797, ATM – 38802, BAP1 – 38803, BLM – 38804, CDH1 – 92568, CDKN2A – 93939, CHEK2 – 93940, EPCAM/MSH2 – 91471, FH – 38805, FLCN – 38806, HOXB13 – 38807, MEN1 – 93942, MITF – 38808, MLH1 – 91460, MSH6 – 91458, MUTYH – 93944, NF1 – 93941, PALB2 – 92571, PMS2 – 91457, PTEN – 92566, RET – 93796, SMARCA4 – 38809, STK11 – 92565, TP53 – 92560, VHL – 93943 |
* All panel components are available individually
Comprehensive and guideline-based hereditary cancer panels
Comprehensive Hereditary Cancer Panel (66 genes)
Test code: 38600
Multi-cancer, 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2
Guideline-Based Hereditary Cancer Panel (32 genes)
Test code: 38611
Multi-cancer, 32-gene panel tests for variants in these genes: APC, ATM, AXIN2, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p16,p14), CHEK2, EPCAM, GREM1, HOXB13, MLH1, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, POLD1, POLE, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53
Cancer-specific panels
Hereditary Breast Cancer Panel (16 genes)
Test code: 38621
Tests for variants in 16 genes predominantly associated with breast, prostate cancer, and other tissues including these genes: ATM, BRCA1, BRCA2, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, STK11, TP53
Hereditary Colorectal Cancer Panel (19 genes)
Test code: 38631
Tests for variants in 19 genes associated with increased risk for colorectal cancer including: APC, AXIN2, BMPR1A, CDH1, EPCAM, GREM1, MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53
Hereditary Endocrine Cancer Panel (12 genes)
Test code: 38641
Tests for variants in 12 genes associated with increased risk for paragangliomas, pheochromocytomas, and endocrine cancer: FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL
BRCA Panel Plus (7 genes)
Test code: 92587
Detects variants in BRCA1, BRCA2, CDH1, PALB2, PTEN, STK11, TP53
Hereditary cancer syndrome panels
Breast cancer syndrome
BRCA Panel (BRCA1, BRCA2)
Test code: 91863
Detects variants in the BRCA1 and BRCA2 genes which are the most common causes of hereditary breast and ovarian cancers
BRCA Ashkenazi Jewish Screen
Test code: 91864
Detects 3 variants within BRCA1 and BRCA2 that are commonly found in the Ashkenazi Jewish population
BRCA Ashkenazi Jewish Screen w/Reflex to BRCA Panel (BRCA1, BRCA2)
Test code: 92140
Ashkenazi Jewish screen; if negative reflex to BRCA Panel-BRCA1 and BRCA2
BRCA1 and BRCA2 Deletion and Duplication
Test code: 91866
Detects large deletion/duplication variants in the BRCA1 and BRCA2 genes which are not detectable by DNA sequencing
Lynch syndrome
Lynch Syndrome Panel (5 genes)
Test code: 91461
Detects pathogenic variants in the MLH1, MSH2, MSH6, PMS2, and EPCAM (del/dup only) genes
Other cancer risks
Nevoid Basal Cell Carcinoma (NBCCS) (Gorlin) Syndrome Panel (PTCH1, SUFU)
Test code: 38651
Detects variants in PTCH1 and SUFU
Tuberous Sclerosis Complex Panel (TSC1, TSC2)
Test code: 38661
Detects variants in TSC1 and TSC2
Juvenile Polyposis Panel (BMPR1A, SMAD4)
Test code: 94053
Detects pathogenic and VUS variants in the BMPR1A and SMAD4 genes
Single-gene and single-site tests
Hereditary Cancer Single Site(s)
Test code: 93945
APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A (p16, p14), CHEK2, DICER1, EGFR, EPCAM, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, GREM1, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2
Single-gene tests*
APC – 93797, ATM – 38802, BAP1 – 38803, BLM – 38804, CDH1 – 92568, CDKN2A – 93939, CHEK2 – 93940, EPCAM/MSH2 – 91471, FH – 38805, FLCN – 38806, HOXB13 – 38807, MEN1 – 93942, MITF – 38808, MLH1 – 91460, MSH6 – 91458, MUTYH – 93944, NF1 – 93941, PALB2 – 92571, PMS2 – 91457, PTEN – 92566, RET – 93796, SMARCA4 – 38809, STK11 – 92565, TP53 – 92560, VHL – 93943
* All panel components are available individually
Simplified ordering process
Easily find detailed information for each test in the Quest Diagnostics test directory and order your Hereditary Cancer test collection kits by completing this online form. To complete the online order form, you’ll need your Quest Diagnostics Account Number.
If you aren’t sure if you have an account, call us at 1.866.MY.QUEST (1.866.697.8378) and we’ll be happy to look it up. We can quickly create an account for you today, so you’ll have everything you need to ensure seamless service—from kit delivery, to speedy order processing, to result delivery—including requisition forms, customer service contact information, and scheduled pick-up service when you need it.
Once your account is set up, ask the Client Services Representative to send your Quest Advanced Hereditary Cancer starter kits to you or complete the online form.
As always, for clinical consultation on test selection and results interpretation, you can call 1.866.GENE.INFO (1.866.436.3463).