Additional hereditary cancer risk tests
About 1 in 3 people in the United States will develop cancer during their lifetime,1 so it’s not uncommon to have many cancers in the same family. Less often, cancers in a family are strongly linked to an inherited gene mutation that is part of a cancer syndrome. Individuals who have a mutation in a cancer predisposition gene have a higher risk for developing certain types of cancer, including: BRCA-related breast, ovarian, and pancreatic cancer; Lynch syndrome; Li-Fraumeni syndrome; or familial adenomatous polyposis.
Certain things make it more likely that cancers in a family are caused by a hereditary cancer syndrome, such as:
- Many cases of the same type of cancer (especially if it is an uncommon or rare type of cancer)
- Cancers occurring at younger ages than usual (typically cancer in someone younger than 50 years old)
- More than 1 type of cancer in a single person (like a person or an individual with both breast and ovarian cancer)
- Cancers occurring in both of a pair of organs (like both eyes, both kidneys, or both breasts)
- Cancer occurring in the sex not usually affected (like breast cancer in a male)
- Cancer occurring in multiple generations (like in a parent, child, and grandchild)
| Test code | Test name | Description | GSP or CPT coding* |
|---|---|---|---|
| 91863 | BRCA Panel (BRCA1, BRCA2) | Detects variants in the BRCA1 and BRCA2 genes which are the most common causes of hereditary breast and ovarian cancers | 81162 |
| 91864 | BRCA Ashkenazi Jewish Screen | Detects 3 variants within BRCA1 and BRCA2 that are commonly found in the Ashkenazi Jewish population | 81212 |
| 92140 | BRCA Ashkenazi Jewish Screen w/Reflex to BRCA Panel (BRCA1, BRCA2) |
Ashkenazi Jewish screen; if negative reflex to BRCA Panel (BRCA1 and BRCA2) | 81212 with possible reflex to 81162 at an additional charge |
| 91461 | Lynch Syndrome Panel (5 genes) | Detects pathogenic variants in the MLH1, MSH2, MSH6, PMS2, and EPCAM (del/dup only) genes |
81295, 81297, 81292, 81294, 81298, 81300, 81317, 81319, 81403 |
| 38651 | Nevoid Basal Cell Carcinoma (NBCCS) (Gorlin) Syndrome Panel (PTCH1, SUFU) |
Detects variants in PTCH1 and SUFU | 81479 |
| 38661 | Tuberous Sclerosis Complex Panel (TSC1, TSC2) | Detects variants in TSC1 and TSC2 | 81405, 81406 (x2), 81407 |
| 94053 | Juvenile Polyposis Panel (BMPR1A and SMAD4) | Detects pathogenic and VUS variants in the BMPR1A and SMAD4 genes | 81405, 81406, 81479 |
Test codes may vary by location. Please contact your local laboratory for more information.
*The CPT® codes provided are based on American Medical Association guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Reference:
1. ACS. Family cancer syndromes. Updated August 5, 2020. Accessed August 10, 2020. https://www.cancer.org/cancer/cancer-causes/genetics/family-cancer-syndromes.html
BRCA Panel (BRCA1, BRCA2)
Test code: 91863
Detects variants in the BRCA1 and BRCA2 genes which are the most common causes of hereditary breast and ovarian cancers
GSP or CPT coding*: 81162
BRCA Ashkenazi Jewish Screen
Test code: 91864
Detects 3 variants within BRCA1 and BRCA2 that are commonly found in the Ashkenazi Jewish population
GSP or CPT coding*: 81212
BRCA Ashkenazi Jewish Screen
w/Reflex to BRCA Panel (BRCA1, BRCA2)
Test code: 92140
Ashkenazi Jewish screen; if negative reflex to BRCA Panel (BRCA1 and BRCA2)
GSP or CPT coding*: 81212 with
possible reflex to
81162 at an
additional charge
Lynch Syndrome Panel (5 genes)
Test code: 91461
Detects pathogenic variants in the MLH1, MSH2, MSH6, PMS2,
and EPCAM (del/dup only) genes
GSP or CPT coding*: 81295, 81297, 81292, 81294, 81298, 81300, 81317, 81319, 81403
Nevoid Basal Cell Carcinoma (NBCCS)
(Gorlin) Syndrome Panel (PTCH1, SUFU)
Test code: 38651
Detects variants in PTCH1 and SUFU
GSP or CPT coding*: 81479
Tuberous Sclerosis Complex Panel (TSC1, TSC2)
Test code: 38661
Detects variants in TSC1 and TSC2
GSP or CPT coding*: 81405, 81406 (x2), 81407
Juvenile Polyposis Panel (BMPR1A and SMAD4)
Test code: 94053
Detects pathogenic and VUS variants in the BMPR1A and SMAD4 genes
GSP or CPT coding*: 81405, 81406, 81479
Test codes may vary by location. Please contact your local laboratory for more information.
*The CPT® codes provided are based on American Medical Association guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Reference:
1. ACS. Family cancer syndromes. Updated August 5, 2020. Accessed August 10, 2020. https://www.cancer.org/cancer/cancer-causes/genetics/family-cancer-syndromes.html
Simplified ordering process
Easily find detailed information for each test in the Quest Diagnostics test directory and order your Hereditary Cancer test collection kits by completing this online form. To complete the online order form, you’ll need your Quest Diagnostics Account Number.
If you aren’t sure if you have an account, call us at 1.866.MY.QUEST (1.866.697.8378) and we’ll be happy to look it up. We can quickly create an account for you today, so you’ll have everything you need to ensure seamless service—from kit delivery to speedy order processing and results delivery—including requisition forms, customer service contact information, and scheduled pick-up service when you need it.
As always, for clinical consultation on test selection and results interpretation, you can call 1.866.GENE.INFO (1.866.436.3463).